Endocrine Abstracts

The Insulin Autoimmune Syndrome (IAS) also called Hirata’s disease consists of hypoglycemia, high insulin concentration and presence of anti-insulin antibodies. IAS is the third leading cause of spontaneous hypoglycemia among Japanese population. The syndrome is exceptionally rare among Caucasians, with <50 cases described in literature.In this report we showcase a 67 year-old female patient. She presented with paroxysmal sweating, daily fatigue...

Typical symptomatology of primary hyperparathyroidism (PNP) includes bone lesions and renal dysfunction in the form of recurrent nephrolithiasis but the symptoms of hypercalcemia may mimic other conditions, including cardiovascular diseases. The exact frequency of cardiac symptoms is not known. The study included 45 adult patients diagnosed with PNP, over 18 years of age, who were qualified for ptx. Laboratory tests included the determination of serum PTH, Ca, Pi and cardiac E...

Objective: To determine the percentage of patients with acromegaly who received lanreotide Autogel 120 mg (ATG120) in extended duration interval and to evaluate the mean costs of ATG120 administered as part of routine care in Poland.Methods: National, multicentre, non-interventional, observational prospective study with 2-years’ time horizon. The study population consisted of adult acromegaly patients who received at least three injections of ATG120...

Introduction: Temozolomide (TMZ) can be administered as the last therapeutic option for aggressive pituitary tumors. Dopamine-agonist resistant prolactinomas are relatively frequent and remain a serious therapeutic problem. GH expressing atypical adenomas are rare and their positive response to TMZ is low. In a general opinion a lack of response to TMZ after three cycles predicts the treatment resistance.The aim of the study was presentation of two patie...

Objective: The aim of the study was to examine characteristics and treatment patterns of Polish acromegalic patients.Methods: A retrospective database analysis was conducted. Adult acromegalic patients treated medically for ≥1 year including at least three injections of lanreotide AUTOGEL 120 were recruited in 36 centres between 29/10/2010 and 31/03/2012. Descriptive analysis was performed to describe demographic and clinical characteristics, treat...

Introduction: Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis and limited therapeutic options. Mitotane is considered as a first-line therapy but only 30% of the patients showing an objective tumour response.Erlotinib and gefitinib (tyrosine kinase inhibitors – TKI) inhibit the epidermal growth factor receptor (EGFR), which is highly expressed and occasionally mutated in various cancers. EGFR expression was found to be a good ...

Introduction: Oncogenic Osteomalacia (OO) is a rare paraneoplastic syndrome, resulting from fibroblast growth factor 23 overproduction. The rarity of the disease and nonspecific symptoms often cause delay in diagnosis by months, or even years. There are two cornerstones in the diagnostic process. The first concerns clinical identification, where awareness of this uncommon ailment combined with hypophosphatemia and clinical signs may be sufficient to identify OO. The second inv...

Poland was considered as a mild-to-moderate iodine deficiency area according to results of a nation-wide survey conducted in early 1990-ties. The obligatory iodine prophylaxis program based on iodization of house-hold salt (30 mg of iodide/1 kg of salt) was therefore introduced in 1997.The aim of the study was to assess the real impact of the Polish iodine prophylaxis model on thyroid volume in schoolchildren.Material and methods: ...

Introduction: Adrenocortical carcinoma (ACC) has a poor prognosis and limited therapeutic options. The epidermal growth factor receptor (EGFR) expression was found to be a good discriminator between malignant and benign adrenal tumours, but was mutated only in 3–10% of ACC cases.Aim: The aim of this study was to assess the effect of inhibition of EGFR with targeted therapies, i.e. Erlotinib (with and without EGF stimulation) on ACC cell proliferatio...

IntroductionTumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused mainly by a phosphaturic mesenchymal tumour (PMT) as a consequence of fibroblast growth factor 23 (FGF23) overproduction. The manifestation of TIO is mostly musculoskeletal. Locating the PMT is usually challenging and a successful surgical resection of the tumour leads to complete recovery.Case presentationA 42-year-old, Ca...